Clinical Studies 2016
Increased Detection of Barrett’s Esophagus-Associated Neoplasia Using Wide Area Transepithelial Sampling in Conjunction with 4-Quadrant Forceps Biopsies: Final Results from a Multi-Center, Prospective, Randomized Trial
Key Findings: Seattle Protocol FB detected 7 cases of HGD/EAC, 6 of which were also detected by WATS3D with the remaining case reported by WATS3D as IND/LGD. WATS3D found an additional 23 cases of HGD/EAC not detected on FB (12 were reported by FB as IND/LGD, while 11 were reported by FB as NDBE only).
Conclusion: WATS3D found 4.1x more HGD/EAC than Seattle Protocol random biopsies.
Published Clinical Studies 2015
Inter-Observer Agreement among Pathologists Using Wide-Area Transepithelial Sampling With Computer-Assisted Analysis in Patients With Barrett’s Esophagus
Key Findings: The diagnosis of BE and associated dysplasia using the WATS technique has very high inter-observer agreement. This appears to be significantly higher as compared with previously published data using standard histopathology.
Data Presented at AGA/ASGE Presidential Plenary Session 2014
Esophageal Brush Biopsy With Computer-Assisted Tissue Analysis Increases Detection Of Barrett’s Esophagus And Dysplasia In A Multi-Site Community-Based Setting
Key Findings: WATS3D with computer-assisted analysis complements standard FB methods to markedly increase detection of BE and dysplasia. This is the largest series reported to date. In light of recent studies and changes to Barrett’s management guidelines, improved dysplasia detection is critical to appropriate management of these pre-cancerous lesions. This study shows that widespread use of WATS3D in community based gastroenterology practices identifies dysplasia missed by FB, leading to improved care for these patients.
Data Presented at American College of Gastroenterology Annual Meeting – 2014
Inter-Observer Agreement Among Pathologists Using the WATS Technique: Wide Area Transepithelial Sampling of Barrett’s Esophagus Using Computer-Assisted Analysis
Key Findings: The diagnosis of Barrett’s esophagus and associated dysplasia using the WATS technique has a very high inter-observer agreement. WATS technique appears to be significantly better inter observer rates compared to previously published data using standard histopathology. This technology represents a significant improvement over current histopathology assessment.
Poster Presented at American College of Gastroenterology Annual Meeting – 2014
Incremental Benefit of Computer-‐Assisted Brush-‐Biopsy (WATS3D) Compared to Standard Endoscopic Biopsy for Detection of Barrett’s Esophagus (BE) and Dysplasia: Systematic Review and Meta‐Analysis
Key Findings: The addition of WATS3D to standard forceps biopsy increases the diagnostic yield for BE and dysplasia in patients undergoing both screening and surveillance.
– The increased yield was highest for patients undergoing screening for BE or post-ablation examinations.
– The number needed to treat (NNT) to detect an additional case of Barrett’s Esophagus ranged from 4-11 based on the 7 available studies.
Posters Presented at ACG 2012
Wide Area Transepithelial Sampling (WATS3D) Improves Detection of Barrett’s Esophagus Following Endoscopic Ablation
Key Findings: WATS3D increased the diagnostic yield from only forceps biopsy by 75% (3/4).
Published Studies 2010
Computer-Assisted Brush-Biopsy Analysis for the Detection of Dysplasia in a High-Risk Barrett’s Esophagus Surveillance Population
Key Findings: These data suggest that computer-assisted brush biopsy is a useful adjunct to standard endoscopic surveillance regimens for the identification of dysplasia in Barrett’s esophagus.
Computer-Assisted Analysis of Abrasive Transepithelial Brush Biopsies Increases the Effectiveness of Esophageal Screening:A Multicenter Prospective Clinical Trial by the EndoCDx Collaborative Group
Key Findings: These results suggest that adjunctive computer-assisted analysis of an abrasive brush biopsy has the potential to substantially improve the detection of Barrett’s esophagus and dysplasia in screening populations.