Finally, you can address the sampling limitations of random forceps biopsy.

  • Barrett’s esophagus (BE) and dysplasia are often missed with 4-quadrant biopsies
  • Wide area sampled by WATS helps find abnormality located between forceps biopsy samples
  • WATS wider area sample sharply increases routine detection of BE and dysplasia (see bar chart)

“At the current time, endoscopists rely solely on taking small random forceps biopsies, at 1-2 cm intervals, leaving more than 96% of the endoscopically suspect area completely untested.”

Prashanth R. Vennalaganti, MD
University of Kansas, School of Medicine, Kansas City, KS


A WATS sample is 50x thicker than a standard 3μ thick histopathology slide


3D imaging yields critical diagnostic information — including the en face view of the gland

  • If standard tissue sectioning were applied to a WATS sample, critical diagnostic information would be destroyed
  • Analogous to a CAT scan, WATS computer imaging synthesizes up to 50, 2D optical slices of each 3 micron focal plane into a single 3D image of the entire 150 micron thick specimen
  • This computer synthesized WATS 3D image presents to the pathologist the in vivo, en face view of the gland — allowing for a definitive diagnosis of dysplasia in cases which would otherwise be reported as “indefinite”

WATS computer synthesis of 50, 2D “optical slices”forms an in vivo 3D image of the uncut glandular surface.


“I see no reason why every academic and community GI should not be using this rapidly performed, easily implemented procedure today to improve the diagnosis of BE and dysplasia, so patients can be directed to appropriate endoscopic surveillance or therapy to prevent esophageal cancer.”

Dr. Charles Lightdale, MD
Columbia University Medical Center, New York


Computer assisted technology yields sharply higher inter-observer agreement among pathologists

  • WATS neural network highlights the most suspicious areas on this computer synthesized image areas for consistent pathologist review

“WATS3D not only addresses the sampling error in…random forceps biopsies, its 3D computer assisted analysis… provides the GI pathologist with diagnostic information that is not typically available using standard…histopathology.”

Robert D. Odze, MD,
Director of the GI Pathology Division, Brigham and Women’s Hospital, Professor of Pathology at the Harvard Medical School